상품화된 성장인자 제품이 다공성 안와충전물의 섬유혈관화에 미치는 영향

• 영문명: The Effects of Commodified Growth Factor Products on the Fibrovascularization of Porous Polyethylene Orbital Implants
• 발행기관: 대한안과학회
• 저자명: 구원모 최준혁 손준혁,Won Mo Gu, MD, Joon Hyuk Choi, MD, PhD, Jun Hyuk Son, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number9, 1366~1371쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.09.15

영문 초록

Purpose: To investigate the effects of commodified growth factor products used clinically on fibrovascular ingrowth into porous polyethylene orbital implants. Methods: Porous polyethylene orbital implant sheets (Medpor^{Ⓡ) soaked with Nepidermin (EasyefⓇ), Trafermin (FiblastⓇ), and normal saline were implanted into the backs of 18 Sprague-Dawley rats. The degree of fibrovascular ingrowth as observed using a light microscope was compared 1 and 2 weeks after implantation and was calculated as a percentage of the fibrovascular ingrowth length. Results: One week after implantation, the percentage of fibrovascular ingrowth length was 25.33 ± 5.43%, 22.56 ± 5.30%, and 21.78 ± 4.66% in the EasyefⓇ-, FiblastⓇ- and normal saline-soaked groups. The degree of fibrovascularization was higher in the EasyefⓇ-soaked group than in the other groups (p = 0.020, 0.012). Two weeks after implantation, the degree of fibrovascularization was 98.33 ± 5.00%, 100.00 ± 0.00%, and 95.89 ± 4.57%, which was significantly higher in the EasyefⓇ-, and FiblastⓇ-soaked groups than in normal saline-soaked group (p = 0.019, <0.001). Conclusions: Commodified growth factor products used in other areas selectively enhanced fibrovascular ingrowth to a greater degree and earlier in ophthalmic plastic and reconstructive surgery. J Korean Ophthalmol Soc 2014;55(9):1366-1371}

키워드

Basic fibroblast growth factor, Epidermal growth factor, Fibrovascularization, Porous polyethylene orbital implant