알레르기결막염 환자에서 눈물 호산구양이온단백질 측정

• 영문명: Tear Eosinophil Cationic Protein Levels in Allergic Keratoconjunctivitis
• 발행기관: 대한안과학회
• 저자명: 임병수 정소향,Byung Su Lim, MD, So Hyang Chung, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number9, 1291~1297쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.09.15

영문 초록

Purpose: To evaluate tear eosinophil cationic protein (ECP) as a severity marker for atopic keratoconjunctivitis (AKC) and seasonal/ perennial allergic conjunctivitis (SAC/PAC). Methods: Tear ECP levels were measured by chemiluminescent immunometric assay in 7 eyes of 7 patients with AKC, 13 eyes of 13 patients with SAC/PAC, and 10 eyes of 10 healthy control subjects. All AKC and SAC/PAC patients underwent conjunctival injection and papillary formation grading. Tear ECP levels were investigated with reference to the clinical parameters of allergic conjunctivitis (papillary formation and conjunctival injection scoring). Results: Tear ECP levels in patients with AKC were significantly higher than those in patients with SAC/PAC and in control subjects (p = 0.012 and p = 0.003, respectively). The number of patients with papillary formation scores of 2-3 was significantly higher in the AKC group than in the SAC/PAC group (p = 0.016). The number of patients with conjunctival injection scores of 2-3 did not significantly differ between the AKC and SAC/PAC groups (p = 0.128). All AKC patients obtained papillary formation scores of 2-3, and tear ECP levels in patients with conjunctival injection scores of 2-3 were significantly higher than in patients with scores of 0-1 in the AKC group (p < 0.001). In the SAC/PAC group, tear ECP levels in patients with papillary formation scores of 2-3 were significantly higher than in patients with scores of 0-1 (p = 0.046). Conclusions: This study suggests that tear ECP was a useful marker to diagnose and assess the severity of disease in patients with AKC as well as SAC/PAC. It would be useful to monitor therapeutic outcome in allergic conjunctivitis. J Korean Ophthalmol Soc 2014;55(9):1291-1297

키워드

Atopic keratoconjunctivitis, Conjunctival injection score, Papillary formation score, Seasonal/perennial allergic conjunctivitis, Tear eosinophil cationic protein