인삼의 Protopanaxadiol계 사포닌으로부터 20(R)-Ginsenoside Rh2 및 20(S) 이성체의 제조

• 영문명: Preparation of a 20(R)-Ginsenoside Rh2 and the 20(S) Epimer from Protopanaxadiol Saponins of Panax ginseng C.A. Meyer
• 발행기관: 대한약학회
• 저자명: 김신일(Shin Il Kim) 백남인(Nam In Baek) 김동선(Dong Seon Kim) 이유희(You Hui Lee) 강규상(Kyu Sang Kang) 박종대(Jong Dae Park)
• 간행물 정보: 『약학회지』제35권 제5호 (1991년), 432~437쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.10.30

영문 초록

A mixture of 20(R)- and 20(S)-ginsenoside Rg3 was obtained under mild acidic hydrolysis from protopanaxadiol saponins, ginsenosides Rb1, Rb2, Rc and Rd. The product was acetylated to give the peracetates, which were further converted into 20(R)-ginsenoside Rg3, 20(S)-ginsenoside Rg3, 20(R)-ginsenoside Rh2 and 20(S)-ginsenoside Rh2 by the direct alkaline treatment depending upon two kinds of temperature conditions respectively. The structure and physicochemical properties of a prosapogenin, 20(R)-ginsenoside Rh2, were investigated.

키워드

20(R)-ginsenoside Rg3 20(S)-ginsenoside Rg3 20(R)-ginsenoside Rh2 20(S)-ginsenoside Rh2 ginseng saponin prosapogenin protopanaxadiol 13C NMR.