Quercetin이 마우스의 면역반응에 미치는 영향

• 영문명: Effects of Quercetin on the Immune Responses in Mice
• 발행기관: 대한약학회
• 저자명: 안영근(Young Keun Ahn) 박영길(Young Gil Park) 김정훈(Joung Hoon Kim)
• 간행물 정보: 『약학회지』제35권 제5호 (1991년), 401~415쪽, 전체 15쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.10.30

영문 초록

Effects of quercetin on the specific and non-specific immune responses were studied in vivo. Quercetin at a dose of 2.5, 5, 10, 20 and 40mg/kg were orally administered to ICR male mice once daily for 28 consecutive days. Cyclophosphamide was injected intraperitoneally to ICR mice with a single dose of 5mg/kg 2 days before secondary immunization. Mice were sensitized and challenged with sheep red blood cells (S-RBC). Immune responses were evaluated by humoral and cellular immune reponses and non-specific immune response. The results of this study were summarized as followings; 1. Quercetin significantly decreased the body weight, and introduced the atrophy of liver, spleen and thymus gland dose-dependently, but increased the numbers of white blood cell. 2. Querectin significantly depressed the hemagglutination titer, Arthus reaction and hemolytic plaque forming cell. 3. Quercetin significantly depressed the delayed type hypersensitivity and rosette forming cell. 4. Quercetin at a dose of 2.5, 5 and 40 mg/kg significantly depressed phagocytic activity. 5. Quercetin at a dose of 10 and 20 mg/kg significantly increased natural killer cell activity.

키워드

Quercetin, humoral immunity cellular immunity phagocytic activity natural killer cell activity number of circulating leukocyte.