푸로푸라놀롤 전처리 가토에서 테오필린의 동태학적 연구

• 영문명: Pharmacokinetics of Theophylline in Rabbits Pretreated with Propranolol
• 발행기관: 대한약학회
• 저자명: 고숙영(Suk Yung Goo) 이진환(Jin Hwan Lee) 최준식(Jun Shik Choi) 범진필(Jin Pil Burm)
• 간행물 정보: 『약학회지』제35권 제5호 (1991년), 379~383쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.10.30

영문 초록

This study was attempted to investigate the pharmacokinetics of theophylline (4 mg/kg i.v) in the rabbits pretreated with propranolol (1 and 2.5 mg/kg/hr, infusion) for four hours. The plasma concentration and AUC of theophylline were increased in rabbits pretreated with propranolol as compared with those of normal rabbits. The amount of cumulative urinary excretion and renal clearance and total body clearance were decreased in rabbits pretreated with propranolol as compared with those of normal rabbits. The apparent volume of distribution was slightly affected by change of the clearance of theophylline. From the results of this experiment, it is desirable that dosage regimen of theophylline should be adjusted when theophylline combined with propranolol in clinical pharmacy practice.

키워드

Pharmacokinetics of theophylline propranolol-pretreated rabbits clearance dosage regimen.