동물성 소염진통제(II) -반묘 및 먹가래 다당체분획의 소염, 진통 및 면역조절작용-

• 영문명: Anti-inflammatory Agents from Animals(II) -Anti-inflammatory, Analgesic and Immunoregulatory Activities of Mylabris sidae and Epicauta gorhami Polysaccharide Fractions -
• 발행기관: 대한약학회
• 저자명: 김창종(Chang Johng Kim) 최충식(Choong Sik Choi) 조승길(Seung Kil Cho)
• 간행물 정보: 『약학회지』제35권 제5호 (1991년), 360~367쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.10.30

영문 초록

Effect of Mylabris sidae(MS) and Epicauta gorhami(EG) polysaccharide fractions on the inflammation and immune responses were studied in vivo. MS and EG contained cantharidin about 0.61 and 0.65%, respectively. It was shown that MS and EG polysaccharide fractions at a oral dose of 100 mg/kg have the significant anti-inflammatory and analgesic activity; They inhibited significantly the carrageenin-induced inflammation and acetic acid-induced writhing syndrome. They accelerated significantly the carbon clearance and the phagocytosis of colloidal carbons by Kupffer cells in liver, but they at a oral dose of 100 mg/kg suppressed significantly the Arthus reaction in the sheep red blood cell(S-RBC)-sensitized mice in accordance with the inhibition of haemaglutinin titer, haemolysin titer and plaque-forming cells. On the other hand, they at a oral dose of 200 mg/kg accelerated slightly the oxazolone-induced dermatitis in rats and delayed hypersensitivity in the S-RBC-challenzed mice in consistent with the increase of rosette forming cells. As the above results, it exhibited that MS and EG polysaccharide fractions inhibited the humoral immune responses, but they accelerated the function of macrophages and cellular immune responses. EG polysaccharide fraction had more active than MS polysaccharide fraction.

키워드

Mylabris sidae Epicauta gorhami polysaccharide fractions anti-inflammatory and analgesic activity antihypersensitivities carbon clearance Kupffer cell phagocytosis S-RBC or oxazolone-induced hypersensitivity.