사염화탄소와 Monosodium-L-Glutamate 병용투여에 의한 간조직의 환원형글루타치온 함량 및 그의 관련효소활성의 변화

• 영문명: Alterations of Glutathione and Glutathione-Dependent Enzyme Activities by Monosodium-L-Glutamate in Rats with Carbon Tetrachloride-Induced Liver Damage
• 발행기관: 대한약학회
• 저자명: 김형춘(Hyoung Chun Kim) 이왕섭(Wang Seop Lee) 전완주(Wan Jhoo Chun) 김수희(Soo Hee Kim) 주왕기(Wang Kee Jhoo)
• 간행물 정보: 『약학회지』제35권 제5호 (1991년), 384~388쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.10.30

영문 초록

To explore the effect of monosodium-L-glutamate(MSG) on CCl4-damaged liver in Wister male rat, 5% MSG solution as drink water were administered after S.C. injection of 0.1 mg/kg CCl4 twice a week for 4 weeks. After last administration of MSG, heptic glutathione(GSH) dependent system was assayed. It showed that MSG increased significantly hepatic glutathione(GSH) and glutathione peroxidase(GSHpx), but decreased glutathione-S-transferase(GST) activity in normal rats. MSG increased significantly the GSHpx. and GST activities in rats with CCl4-induced liver damage. These results indicate that decrease of GSH dependent systems in CCl4 liver injury might be partially elevated by coadministration of MSG.

키워드

CCL4-damaged liver GSH dependent system monosodium-L-glutamate.