Clonidine의 혈압강하 및 적출정관 평활근수축에 미치는 6-Hydroxydopamine의 영향

• 영문명: The Effect of 6-Hydroxydopamine on the Hypotensive Action and Contractile Force of Isolated Vas Deferens Smooth Muscle by Clonidine
• 발행기관: 대한약학회
• 저자명: 윤재순(Jae Soon Yun) 장문희(Moon Hee Chang)
• 간행물 정보: 『약학회지』제31권 제2호 (1987년), 82~91쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.04.30

영문 초록

The effect of neurotoxic compound 6-hydroxydopamine (6-OHDA) on the change in blood pressure and contractile response of Vas deference by centrally acting agents has been studied in normal and DOCA-salt induced hypertensive rats. The treatment of neonatal rats with 6-OHDA (2 X 1OOmg, 250mg Kg-1 s.c) significantly inhibited the antihypertensive and relaxant effects of Vas deference of clonidine(100mcg Kg-1 iv.). The simultaneous administration of desipramine with clonidine into neonatal rats decreased the antihypertensive response of clonidine although treated did not affect the relaxative response of Vas deference. Furthermore, the antihypertensive and relaxant responses of clonidine were reduced by the neonatal rats with 6-OHDA regardless of the administration of desipramine. When neonatal rats were administered with 6-OHDA, the development of DOCA-salt hypertension was prevented. These results suggest that 6-OHDA, clonidine and desipramine had a significant effect on the development and the inhibition of central hypertension mediating the central adrenergic neuron due to their affinity to the central nervous system.