Lyophyllum decastes의 항암성분의 면역학적 연구(I)

• 영문명: Immunological Studies on Antitumor Component of Lyophyllum decastes(I)
• 발행기관: 대한약학회
• 저자명: 이정옥(Chong Ock Lee) 최응칠(Eung Chil Choi) 김병각(Byong Kak Kim)
• 간행물 정보: 『약학회지』제31권 제2호 (1987년), 70~81쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.04.30

영문 초록

To elucidate action mechanism of lyophyllan A, an antitumor polysaccharide of Lyophyllum decastes, its immunological activities were examined. Lyophyllan A increased significantly the weights of spleen and liver of mice. Lyophyllan A also restored the decreased thymic weight in tumor-bearing mice. It did not show any direct cytotoxicity against tumor cells, but showed immunopotentiating activities by increasing the number of the plaques in hemolytic plaque assays. Lyophyllan A increased the number of peritoneal exudate cells (PEC) and inhibited the growth of sarcoma 180 mixed with PEC. Moreover the macrophages from lyophyllan A-treated mice exhibited a strong cytotoxic activity towards L5178Y target cells.