Zipeprol 내용액제의 고미교정에 관한 연구

• 영문명: The Mitigation of Bitterness of Zipeprol Solution
• 발행기관: 대한약학회
• 저자명: 김종국(Chong Kook Kim) 최한곤(Han Gon Choi)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 42~44쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

Zipeprol, anti-tussive, is considerably bitter. Therefore, it is necessary to mitigate the bitterness in zipeprol syrup for children. In this experiment, it was attempted to mitigate the bitterness of zipeprol by means of polymers such as beta-cyclodextrin, arabic gum, HPMC(hydroxypropyl methylcellulose), PEG 2000(polyethyleneglycol 2000), PVP(polyvinylpyrrolidone). Caffeine was used as the reference standard of bitterness. In the result of this experiment, beta-cyclodextrin would mitigate the bitterness of zipeprol more largely than any other polymers. Arabic gum was the second choice which would mitigate the bitterness of zipeprol.