폴리에틸렌 옥사이드-실리콘 Segment Device에서 헤파린 용출

• 영문명: Heparin Release from Polyethyleneoxide-Polydimethylsiloxane Devices
• 발행기관: 대한약학회
• 저자명: 김성호(Sung Ho Kim)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 306~310쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

The release of heparin from monolithic devices composed of different ratios of polyethylene oxide(PEO MW 20,000) and polydimethylsiloxane was investigated. Water soluble PEO plended into the polydimethylsiloxane proved a controlled release of heparin. The release rate of heparin could be controlled by varying the content of PEO and loading dose of heparin. The release rate of heparin from the devices increased as the content of PEO and heparin in the devices increased. The release rate of heparin from devices were related to nature of solute(ionic strength) and temperature. The release mechanism may be associated with the creation of pore or domine through the devices the water-uptake and the change in the physical structure of the polydimethylsiloxane network.