아세트아미노펜 체내동태의 용량의존성에 관한 연구

• 영문명: Dose-Dependent Pharmacokinetics of Acetaminophen in the Rat
• 발행기관: 대한약학회
• 저자명: 이삼수(Sam Soo Lee) 심창구(Chang Koo Shim) 이민화(Min Hwa Lee) 김신근(Shin Keun Kim)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 301~305쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

Dose-dependent pharmacokineties of acetaminophen was studied in the rat. Acetaminophen was injected intravenously at doses of 10, 30, 50, 100 and 200mg/kg to the adult male rats. The well-known dose-dependent pharmacokinetic behavior was found even at 30mg/kg dose. It implies that metabolism of acetaminophen in the liver, probably sulfation, is saturated at very low concentration of acetaminophen. Dosage regimen establishment based on this characteristics would be necessary even at usual does level (300-600mg/day/body).