Methyl-7-iodoheptanoate의 합성에 관한 연구

• 영문명: Study on Synthesis of Methyl-7-iodoheptanoate
• 발행기관: 대한약학회
• 저자명: 심영섭(Young Sup Shim) 최종욱(Jong Wook Choi) 김완주(Wan Joo Kim) 박호군(Ho Koon Park) 박영숙(Young Sook Park)
• 간행물 정보: 『약학회지』제30권 제6호 (1986년), 348~351쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.12.30

영문 초록

New synthetic method for methyl-7-iodoheptanoate was studied. Methyl-7-iodoheptanoate is important compound in the synthesis codlemone, the sex pheromone of codling moth which doing harm to apple tree significantly, and this compound also be used essentially in the synthesis of prostaglandin derivatives. In previous the methyl-7-iodoheptanoate has been prepared from-7-chloroheptanoic acid as a starting material with disadvantage, since the 7-chloroheptanoic acid is expensive and the process is much complicate. In this paper the method to preparing methyl-7-iodoheptanoate was developed economically by using dihydropyran as a starting material in the course of 5 steps. Hence, methyl-7-iodoheptanoate which can be synthesized by new method studied on this paper should be very useful compound for preparing codlemone or its acetate which will be used to developing pollution-free insecticides, and for preparing prostaglandin derivatives with advantage.