황기의 저밀도지질단백질(LDL)산화에 미치는 영향

• 영문명: Effect of Astragali Radix on Low Density Lipoprotein Oxidation
• 발행기관: 대한약학회
• 저자명: 김은정(Eun Jeong Kim) 양기숙(Ki Sook Yang)
• 간행물 정보: 『약학회지』제45권 제5호 (2001년), 529~535쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.10.31

영문 초록

The root of Astrogalus membranaceus Bunge (Leguminosae), which has been used for the treatment of hypertension, chronic hepatitis, duodenal ulcers, chronic nephritis and promotion of immunity in folk remedies. Several lines of evidence indicate that oxidative modification of low-density lipoprotein (Ox-LDL) may play an important role in atherogenesis. Hence, the role of antioxidants in the prevention of LDL oxidation needs to be determined. To investigate the antioxidant activity we determined the MeOH ex. And fractions of Astragali Radix on the inhibition of LDL oxidation. The CH2Cl2 and EtOAc frations inhibited the oxidative modification of LDL by a decrease in the lipid peroxide content and the electrophoretic mobility of LDL. Calycosin-7-0-β-D -glucoside which was isolated from EtOAc fraction inhibits the oxidative modification of LDL.

키워드

Astragali Radix low density lipoprotein oxidation Calycosin-7-O-beta-D-glucoside.