천연물로부터의 세포내 효소 활성 조절물질의 탐색 및 기능 연구: 갈근의 알코을 탈수소효소 저해 활성 성분

• 영문명: Studies on the Screening of Bioactive Compound Acting on Intracellular Enzymes from Natural Products and Its Mode of Action : Inhibitory Component of Puerariae Radix on Alcohol Dehydrogenase Activity
• 발행기관: 대한약학회
• 저자명: 이현주(Hyun Joo Lee) 오민아(Min Ah Oh) 최영희(Young Hui Choi) 이강만(Kang Min Lee)
• 간행물 정보: 『약학회지』제45권 제5호 (2001년), 500~505쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.10.31

영문 초록

Puerariae Radix is one of the medicinal plants used in oriental medicine for hangover. It has been claimed for several pharmacological effects including anti-alcohol abuse, antidipsotropic activity and anti-alcohol intoxication. In connection with Puerariae Radix effects, an activity-guided purification of active substance on alcohol dehydrogenase (ADH) was carried-out. The most active compound was isolated as puerarin (C21H2OO9), molecular weight 416. Puerarin inhibited ADH noncompetitively against ethanol or NAD+.

키워드

Puerariae radix alcohol dehydrogenase noncompetitive inhibition.