trans- Cinnamaldehyde 유도체의 항진균활성 검색

• 영문명: Antifungal Activities of trans-Cinnamaldehyde Derivatives
• 발행기관: 대한약학회
• 저자명: 방규호(Kyu Ho Bang) 조근희(Gune Hee Jo) 이영하(Young Ha Rhee)
• 간행물 정보: 『약학회지』제45권 제5호 (2001년), 431~436쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.10.31

영문 초록

Antifungal activities of trans-cinnamaldehyde (CA) derivatives including commercial CA derivatives as well as synthesized CA derivatives against various human pathogenic fungi were investigated. Among the derivatives tested, α- chlorocinnamaldehyde, α-bromocinnamaldehyde and α-phenyl-2,4,6-heptatrienal were more potent than CA in antifungal activity α-Bromocinnamaldehyde was the most effective in inhibiting the growth of representative fungi of dermatomycosis with minimum inhibitory cocentration (MIC) of 0.61∼9.76μg/ml. In the structure-activity relationship, introduction of the chlorine and bromine group into the C-2 of CA resulted in the decrease of MIC. Derivative with more double bands exhibited the increase of antifungal activity against various pathogenic fungi.

키워드

trans-Cinnamaldehyde antifungal activity cinnamaldehyde derivatives.