합성기질 및 응고시간을 이용한 혈액응고 제8인자 역가측정법

• 영문명: Potency Assay of Factor VIII : C Concentrates using the Chromogenic and Clotting Assay
• 발행기관: 대한약학회
• 저자명: 강혜나(Hye Na Kang) 김순남(Soon Nam Kim) 허숙진(Sook Jin Hur) 홍성화(Seung Hwa Hong)
• 간행물 정보: 『약학회지』제45권 제5호 (2001년), 476~483쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.10.31

영문 초록

The clotting assay was replaced by the chromogenic substrate assay which is recommended by the European Pharmacopoeia (EP) and the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis based on the reliability convenience and simplicity of the chromogenic assay: A correlation study was carried out with a one-stage factor VIII : C clotting assay and the perfonnance of the chromogenic assay was evaluated using two test kits that fulfilled the requirements of EP for factor VIII concentrates test. Although chromogenic assay has partly differences in measurement principle and standardization, this assay has a high correlation with clotting assay in various types of factor VIII concentrates and factor Vlll standard. We conclude that the chromogenic assay for factor VIII : C con- centrates correlates well with the clotting assay and shows good analytical performance.

키워드

Chromogenic substrate assay clotting assay coagulation factor VIII.