아스파라톤에 의한 사이클로옥시나제의 저해 - in Vitro

• 영문명: In Vitro Inhibition of Cyclooxygenase by Aspalatone
• 발행기관: 대한약학회
• 저자명: 서대연(Dae Yeon Suh) 한병훈(Byung Hoon Han)
• 간행물 정보: 『약학회지』제39권 제5호 (1995년), 565~568쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.10.30

영문 초록

A new antiplatelet agent, aspalatone ([3-(2-methyl-4-pyronyl)]-2-acetyloxybenzoate) was demonstrated to inhibit MDA generation from arachidonic acid catalyzed by partially purified bovine seminal vesicle cyclooxygenase. This inhibition was also observed with acetylsalicylic acid. The results suggest that the mechanism for the antiplatelet effect of aspalatone is, like acetylsalicylic acid, due to its inhibition of cyclooxygenase.