비이온성 미셀용액과 수중유형 마이크로에멀젼계의 특성 및 수단 IV의 가용화

• 영문명: Characteristics of Non-ionic Micellar and O/W Microemulsion Systems and Solubilization of Sudan IV
• 발행기관: 대한약학회
• 저자명: 지웅길(Ung Kil Jee) 황성주(Sung Joo Hwang) 장은옥(Eun Ok Chang) 현종목(Jong Mok Hyun)
• 간행물 정보: 『약학회지』제39권 제5호 (1995년), 495~505쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.10.30

영문 초록

The O/W microemulsion systems were made from 2 or 4% (w/w) oil (soybean oil, olive oil or isopropyl myristate) and 10, 15 or 20% (w/w) Brij 96. They were compared with micellar solution of equivalent surfactant concession in terms of physicochemical properties, and the solubilization of sudan IV. They were characterized by dynamic light scattering, stability, surface tension, viscosity and rheogram. The mean diameters Of O/W microemulsion systems were 10~15nm, and those of Brij 96 micellar solutions were 18~19nm. Both of them were monodisperse systems. The O/W microemulsion systems showed Newtonian flow and their apparent viscosities were lower than those of micellar solutions. The surface tensions of O/W microemulsion systems were increased or decreased depending on the types of oil used, when compared with those of micellar solutions. The O/W microemulsion systems were very stable, and did not show any flocculation or aggregation. Their mean diameters were not changed after three months. But oxidation was observed in microemulsions without nitrogen gas at high temperature. There was a significant improvement in the sudan IV solubilization in microemulsion compared with that in the micellar solution containing equivalent concentration of surfactant. The size distribution and mean diameters of O/W microemulsions were not changed when sudan IV was solubilized.