글리시르히진이 3T3-L1 세포의 분화에 미치는 영향

• 영문명: Effect of Glycyrrhizin on the Differentiation of 3T3-L1 Cell
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 염정열(Jeong Yul Yum) 오석흥(Suk Heung Oh) 권진(Jin Kweon) 강성룡(Sung Young Kang) 오찬호(Chan Ho Oh) 소준노(Joon No So) 전훈(Hoon Jeon)
• 간행물 정보: 『약학회지』제39권 제5호 (1995년), 535~540쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.10.30

영문 초록

The purpose of this research was to investigate effects of glycyrrhizin on the differentiation of preadipocytes, 3T3-L1 cells and to characterize the action of glycyrrhizin that affect the responses of 3T3-L1 cells during differentiation. The differentiation of 3T3-Ll cells was stimulated by glycyrrhizin, and triglyceride contents was increased in the dffrerentiated 3T3-L1 cell extracts. Total protein contents was increased by glycyrrhizin or inductive agents in the differentiated 3T3-L1 cell extracts. Calmodulin contents was increased by inductive agents, but the contents was not affected by glycyrrhizin in the differentiated 3T3-L1 cell extracts. The results suggest that glycyrrhizin has a stimulating activity of adipose conversion, but the activity is not related to calmodulin contents during the process of differentiation of 3T3-L1 cells.