방선균 분리주 No. 2511-5로부터 포스포리파제 C 저해물질 스코파훈진의 분리

• 영문명: Isolation of Scopafungin, a Potent Inhibitor of Phospholipase C from Actinomycetes isolate No. 2511-5
• 발행기관: 대한약학회
• 저자명: 오원근(Won Keun Oh) 이현선(Hyun Sun Lee) 안순철(Soon Cheol Ahn) 김보연(Bo Yeon Kim) 박문수(Moon Su Park) 민태익(Tae Ick Mheen) 안종석(Jong Seog Ahn)
• 간행물 정보: 『약학회지』제39권 제5호 (1995년), 554~559쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.10.30

영문 초록

MT 2511-5 was purified as a inhibitor of phospholipase C(PLC) from culture broth of a Streptomyces sp. NO. 2511-5. It was identified as scopafungin, 36-membered marcrolide by physicochemical and spectroscopic data. Its IC50 was 30mcM against phospholipase C and it also showed inhibitory activity against some fungi.