5-(2''-(N-(1-메틸-3-(3''-카바밀페닐)-n-프로필))아미노에틸)-8-히드록시-4-메틸카보스티릴 유도체의 합성 및 안정성 연구

• 영문명: Synthesis and in Vitro Stability Evaluations of 5-(2''-(N-(1-methyl-3''-carbamylphenyl)-n-propyl))aminoethyl)-8-hydroxy-4-methylcarbostyril Derivatives
• 발행기관: 대한약학회
• 저자명: 윤성화(Sung Hwa Yoon) 박규순(Gyoo Soon Park)
• 간행물 정보: 『약학회지』제39권 제5호 (1995년), 506~510쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.10.30

영문 초록

The 5-(2''-(N-(l-methyl-3''-carbamylphenyl)-n-propyl))aminoethyl)-8-hydroxy-4-methyl- carbostyril derivatives which have isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O-Methyltransferase (COMT) vulnerable m-hydroxy group were synthesized via 7 synthetic steps, and their stabilities in phosphate buffer solution(pH=7.4), human blood, 80% human plasma and 20% rat liver homogenate were determined in vitro condition,