Flavone의 합성 중간체인 2-Aroxyloxyacetophenone류의 새로운 합성법

• 영문명: Synthesis of 2-Aroxyloxyacetophenones as Intermediates for Flavone Synthesis
• 발행기관: 대한약학회
• 저자명: 송규용(Gyu Yong Song) 안병준(Byung Zun Ahn)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 1~5쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

We have synthesized some 2-(2-benzyloxybenzoyloxy)-and 2-(2,6-dibenzyloxybenzoyloxy)-acetophenones as intermediates for flavone synthesis. The reaction of polyoxygenated 2-hydroxyacetophenones with 2-benzyloxybenzoic acid or 2,6-dibenzyloxybenzoic acid in the presence of dicyclohexylcarbodiimide and p-dimethylaminopyridine resulted in a good yield(70-89%) of 2-(2-benzvloxybenzovloxy)-acetophenones or 2-(2,6-dibenzyloxybenzoyloxy)-acetophenones under milder conditions and in shorter time than the previous methods. This new methods using benzoic acids instead of benzoyl chlorides saves one reaction step of acid chlorination in comparision of the previous methods.