Streptozotocin 유도 당뇨병 랫드의 혈소판 Phospholipase A2 활성에 미치는 Hydroxybrazilin의 영향

• 영문명: Inhibitory Effects of Hydroxybrazilin on the Platelet Phospholipase A2 Activities in Normal and Streptozotocin Induced Diabetic Rats
• 발행기관: 대한약학회
• 저자명: 문창현(Chang Hyun Moon) 임동순(Dong Soon Lim) 조태순(Tae Soon Cho) 김지영(Ji Young Kim)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 97~101쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

Platelets play a very important role in normal hemostasis and their functions are more enhanced in various pathogenic states than in normal state. Especially it has been postulated that abnormal platelet and endothelium function might be major factors of microcirculatory disturbance in diabetes mellitus. Hydroxybrazilin, a phenolic constituent of Hematoxylon campechianum has been examined for its inhibitory effect on platelet aggregation. Its antiaggregatory effect might be mediated through the decrease of ATP release from dense granule and those of thromboxane A2 production in normal and streptozotocin induced diabetic rats. The present study was undertaken to gain insight into the mechanism that hydroxybrazilin inhibited thromboxane A2 production in platelets. Thus we measured the effect of hydroxybrazilin on phospholipase A2, a rate limiting step of thromboxane A2 production, in normal and streptozotocin induced diabetic rats. Hydroxybrazilin significantly inhibited the platelet phospholipase A2 activity in normal and streptozotocin induced diabetic rats.

키워드

Platelet phospholipase A2 Streptozotocin-induced diabetic rat Hydroxybrazilin.