천련자로부터 분리한 Limonoid 성분의 세포독성

• 영문명: The Cytotoxic Limonoid From the Fruits of Melia Toosendan
• 발행기관: 대한약학회
• 저자명: 김영호(Young Ho Kim) 황방연(Bang Yeon Hwang) 김세은(Se Eun Kim) 김환묵(Hwan Mook Kim) 오구택(Goo Taeg Oh) 노재섭(Jai Seup Ro) 이경순(Kyong Soon Lee) 이정준(Jung Joon Lee)
• 간행물 정보: 『약학회지』제38권 제1호 (1994년), 6~11쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.02.28

영문 초록

The MeOH extract of the fruits of Melia toosendan was selected for futher study by its cytotoxicity and effect on the human breast cancer cell line, MCF-7. The active principle obtained by activity guided fractionation followed by purification gave rise to a needle crystal. The structure was deduced by employing NMR and was determined to be identical with 28-deacetyl sendanin by comparison with published data. This compound induced morphological change of MCF-7 to be rounded with tubule at concentrations between 50mcg/ml and 0.025mcg/ml. This compound, however, showed strong cytotoxic effect on Hepa1c1c7 and HepG2, and their GI50 on the hepatoma cell lines were 0.238mcg/ml and 0.805mcg/ml, respectively. Its effect on lymphocyte of mouse was stronger than hepatoma cell lines, and their ED50 of polyclonal antibody response was 0.011mcg/ml, and ED50 of cell viability was 0.039mcg/ml.

키워드

Melia toosendan Meliaceae MCF-7 antitumor 28-deacetyl sendanin.