클로로프로파미드와 싸이클로덱스트린과의 포접 화합물에 관한 연구

• 영문명: Inclusion Complexation of Chlorpropamide with Cyclodextrins
• 발행기관: 대한약학회
• 저자명: 정경혜(Kyeong Hye Jeong) 김길수(Kil Soo Kim) 구영순(Young Soon Ku)
• 간행물 정보: 『약학회지』제30권 제2호 (1986년), 87~95쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.04.30

영문 초록

Inclusion complexation of alpha-cyclodextrin(alpha-CD), beta-cyclodextrin(beta-CD) and tri-0-methyl-beta-cyclodextrin(tri-0-methyl-beta-CD) with chlorpamide(CPA) in aqueous solution and in the solid state were studied by the solubility method, spectroscopy (UV, IR), differential scanning calorimetry (DSC) and powder X-ray diffractometry, and all their molar ratios were found to be 1:1. The solid complexes of CPA with three kinds of cyclodextrins were prepared by a freeze-drying method, and their dissolution behaviors were examined. As a result, the release of CPA from the inclusion complexes was significantly improved. The intrinsic dissolution rate of CPA in cyclodextrin inclusion complexes was about 51 times (alpha-CD inclusion complex) and 12 times (beta-CD inclusion complex) larger than that of intact CPA.