Dithiocarbohydrazone류의 합성과 항균작용에 관한 연구(I) 2-Formylpyridine Dithiocarbohydrazone류 및 이들의 Cu(II) 착물

• 영문명: Synthesis and Antimicrobial Activity of Dithiocarbohydrazones(I) 2-Formylpyridine Dithiocarbohydrazones and Their Cu(II) Chelates
• 발행기관: 대한약학회
• 저자명: 최보길(Bo Gil Choi)
• 간행물 정보: 『약학회지』제30권 제2호 (1986년), 79~86쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.04.30

영문 초록

In order to study 2-formylpyridine dithiocarbohydrazones (DTCH''s) and their Cu(II) chelates as potential effective antimicrobial agents, twelve new compounds of six DTCH''s and their Cu(II) chelates were synthesized. The compositions of Cu(II) chelates were determined on the basis of the data obtained from elemental analysis, electronic and IR spectrophotometry, and other method. They were tested for antimicrobial activity in vitro against a gram-positive, seven gram-negative bacterial species and three fungal species. DTCH''s exhibited high antibacterial activity against the gram-positive Staphylococcus aureus, but low activity against the various gram-negative bacterial species. In contrast to DTCH'S, their Cu(II) chelates exhibited higher antibacterial activity against St. aureus, but weaker, if any, activity against the gram-negative bacterial species. Both DTCH''s and their Cu(II) chelates showed relatively potent antifungal activity against Cryptococcus neoformans, but weak activity against Candida albicans and Candida pseudotropicalis.