Sodium Taurodeoxycholate가 간장해 Rat에서 메틸렌 블루의 체내분포와 소실에 미치는 영향

• 영문명: Effect of Sodium Taurodeoxycholate on the Disposition and Elimination of Methylene Blue in the Rats of Experimental Hepatic Failure
• 발행기관: 대한약학회
• 저자명: 권오승(Oh Seung Kwon) 심창구(Chang Koo Shim) 이민화(Min Hwa Lee) 김신근(Shin Keun Kim)
• 간행물 정보: 『약학회지』제30권 제2호 (1986년), 68~72쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.04.30

영문 초록

Effect of sodium taurodeoxycholate (TDC) on the pharmacokinctics of methylene blue (MB) was investigated in the rats of experimental hepatic failure induced by CCl4. Intravenous infusion of TDC increased the distribution volume of central compartment (Vd1) and the total body clearance (CLt) of MB. Increased lipophilicity through ion-pair formation with TDC seemed to be the probable cause of increased Vd1, and CLt.