약-약 상호작용 연구(IV) Warfarin의 혈장단백 결합에 대한 Niflumic Acid 및 Phenylbutazone의 영향 비교

• 영문명: A Comparative Study of the Influence of Miflumic Acid and Phenylbutazone on Wafarin-Plasma Protein Binding
• 발행기관: 대한약학회
• 저자명: 조윤성(Yun Sung Chough) 양중익(Joong Ik Yang)
• 간행물 정보: 『약학회지』제24권 제2호 (1980년), 97~100쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.06.30

영문 초록

To determine in vitro effects of phenylbutazone and niflumic acid on warfarin binding to rabbit serum protein, warfarin was added to the rabbit plasma, and the bound fraction was determined by warfarin-protein complex fluorescence. The bound fraction was decreased by phenylbtazone and niflumic acid. From this effect niflumic acid was found to have the more potent ability to displace warfarin from protein binding sites than phenylbutazone.