회첨 엑기스의 혈압에 미치는 영향(I)

• 영문명: Effects of Siegesbeckiae Herba Extracts on the Blood Pressure of Rabbits(I)
• 발행기관: 대한약학회
• 저자명: 김성원(Sung Won Kim) 고석태(Suk Tai Ko)
• 간행물 정보: 『약학회지』제24권 제2호 (1980년), 101~110쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.06.30

영문 초록

To investigate the effects of Siegesbeckiae Herba on the blood pressure, this study was carried out in the whole and the spinal rabbits, using its water and ethanol extracts. When Siegesbeckiae Herba water extract (SGWE) and ethanol extract (SGEE) were administered into the whole rabbits by route of ear vein, both of them produced fall of blood pressure. The difference between these two extracts was that SGEE is more potent than SGWE. The depressor effects of SGWE and SGEE were not affected by vagotominization but inhibited by pretreatment of atropine. The depressor responses of the whole rabbits to intravenous SGWE and SGEE were weakened by treatment of animals with bethanidine or phentolamine but not by propranolol. Pretreatment of the whole rabbits with diphenhydramine significantly weakened the depressor effects of SGEE. Infusion of SGWE and SGEE in the whole rabbits did not influence the presser effects caused by angiotensin, norepinephrine or carotid artery occlusion. SGEE, when given into the lateral ventricle of the whole rabbits or into the vein of the spinal rabbits, elicited fall of blood pressure, respectively.