일산화탄소 중독시 식초산이 혈액 반응에 미치는 영향

• 영문명: The Hemato-Chemical Effect of Acetic Acid Treatment on Carbon Monooxide Intoxication
• 발행기관: 대한약학회
• 저자명: 윤연화(Youn Hwa Yoon) 정용(Yong Chung) 권숙표(Sook Pyo Kwon)
• 간행물 정보: 『약학회지』제24권 제2호 (1980년), 79~86쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.06.30

영문 초록

CO-intoxication is a serious problem in public health since the coal briquette has been used as one of fuels from 1950''s. It has been discussed that the treatment with acetic acid vapor may be effective for CO-intoxication. This study was undertaken to investigate the action of acetic acid therapy, comparing with the spontaneous air treatment The acetic acid vapor was introduced to the blood combined with CO(in vivo and in vitro). The dissociation of COHb, the production of COHb, the levels of Hb and adrenaline and nor-adrenaline were measured. The effect of acetic acid vapor on dissociation of COHb was about 7~9% more effective than the spontaneous air treatment. The acetic acid vapor treatment for the dissociation of COHb was similar effect to the spontaneous air treatment. In an experiment of the combining CO gas with blood, the acetic acid vapor treatment was less effective in the production of COHb than that of spontaneous air treatment. Treatment with the acetic acid vapor to rabbit intoxicated with CO gas induced a little amount of Hb in blood comparing with the spontaneous air treatment. But, it is not a significant increment statistically. By the acetic acid vapor treatment after CO gas intoxication the adrenaline was increased and noradrenaline was decreased. With these results, it is assumed that the effect of acetic acid therapy on CO-gas intoxication would be caused by inductions of Hb and adrenaline and to be reduction of nor-adrenaline.