대구지역 일개 대학병원에서 분리된 Acinetobacter baumannii의 항균제 내성현황과 분자역학적 특성

• 영문명: Antimicrobial Resistance and Molecular Epidemiologic Characteristics of Acinetobacter baumannii Isolated from a University Hospital in Daegu, Korea
• 발행기관: 한국보건기초의학회
• 저자명: 이승진 박민정 박현욱 유성률 우현준
• 간행물 정보: 『한국보건기초의학회지』제16권 제2호, 230~237쪽, 전체 8쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2023.12.31

국문 초록

Acinetobacter baumannii is a gram-negative bacterium that causes nosocomial infections, such as ventilator-associated pneumonia, bacteremia, and urinary tract infections, particularly in immune-compromised patients. A. baumannii has a remarkable capacity to acquire mechanisms that confer resistance to various types of antibiotics. Therefore, rapid and sensitive molecular detection in clinical isolates is greatly needed for the appropriate therapy and outbreak control of Multi drug resistant A. baumannii (MDRAB). This study was conducted for the purpose of a basic study on the current status of antimicrobial resistance and types of resistance mechanisms in MDRAB by confirming the resistance patterns and distribution of the major antimicrobial resistance genes of A. baumannii isolated from a university hospital in Daegu City. All 512 isolates carried blaOXA-23 and blaOXA-51 genes, showing resistance to carbapenems. In addition, resistance genes to aminoglycosides and 16S rRNA methylase were retained at high frequency. Sequencing analysis demonstrated that the resistance to Quinolones was acquired by amino acid substitution due to point mutation occurring at position 83 (Ser83) of gyrA and position 80 (Ser80) of parC. In the REP-PCR profile, all isolates showed band patterns similar to each other and were analyzed to belong to a common cluster by dendrogram. This suggests that A. baumannii, which originated from a common ancestor, has spread clonally within hospitals or communities. Thus, it is necessary to continuously monitor the antimicrobial resistance rate and resistance gene distribution to establish a system that can detect in hospital transmission or regional spread early.

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A. baumannii MDRAB Antimicrobial resistance REP-PCR