학술논문
Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes
이용수 2
- 영문명
- Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Junxiong Zhao Qian Wu Ting Yang Liangui Nie Shengquan Liu Jia Zhou Jian Chen Zhentao Jiang
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제26권 제6호, 541~556쪽, 전체 16쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2022.11.30
4,720원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO2) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2. However, exogenous SO2 donors could up-regulate AAT1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO2 can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
FUNDING
ACKNOWLEDGEMENTS
CONFLICTS OF INTEREST
REFERENCES
해당간행물 수록 논문
- Thermotherapy as an alternative to exercise for metabolic health in obese postmenopausal women: focus on circulating irisin level
- Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes
- Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca2+-spikes and cell death in cultured rat hippocampal neurons
- Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells
- The physiological and pharmacological roles of prostaglandins in hair growth
- The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy
- Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain via regulation of brain-derived neurotropic factor
- Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway
- The WNT/Ca2+ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria
- Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells
- Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells
- Cell-cell contacts via N-cadherin induce a regulatory renin secretory phenotype in As4.1 cells
- Corrigendum to: Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion
- Lactate promotes vascular smooth muscle cell switch to a synthetic phenotype by inhibiting miR-23b expression
참고문헌
관련논문
의약학 > 의학일반분야 BEST
- 교육전담간호사가 주도하는 임상현장교육 프로그램이 신규 간호사의 간호업무성과와 교육 만족도에 미치는 효과
- 간호대학생의 MBTI 성격유형별 의사소통능력, 자아존중감, 학업성취도의 관계
- 일반인을 위한 해부학 만화
의약학 > 의학일반분야 NEW
- Glucocorticoids improve sperm performance in physiological and pathological conditions: their role in sperm fight/flight response
- A comprehensive review of the mental spine
- The anatomical variations of median nerve in Shiraz, Iran
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!