Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway

• 영문명: Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Wei Fu Xiaowei Fang Lidong Wu Weijuan Hu Tao Yang
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제26권 제6호, 511~518쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2022.11.30

영문 초록

Sepsis-associated myocardial injury, an invertible myocardial depression, is a common complication of sepsis. Neogambogic acid is an active compound in garcinia and exerts anthelmintic, anti-inflammatory, and detoxification properties. The role of neogambogic acid in sepsis-associated myocardial injury was assessed. Firstly, mice were pretreated with neogambogic acid and then subjected to lipopolysaccharide treatment to induce sepsis. Results showed that lipopolysaccharide treatment induced up-regulation of biomarkers involved in cardiac injury, including lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and troponin I (cTnI). However, pretreatment with neogambogic acid reduced levels of LDH, CK-MB, and cTnI, and ameliorated histopathological changes in the heart tissues of septic mice. Secondly, neogambogic acid also improved cardiac function in septic mice through reduction in left ventricular end-diastolic pressure, and enhancement of ejection fraction, fractional shortening, and left ventricular systolic mean pressure. Moreover, neogambogic acid suppressed cardiac apoptosis and inflammation in septic mice and reduced cardiac fibrosis. Lastly, protein expression of p-p38, p-JNK, and p-NF- κB in septic mice was decreased by neogambogic acid. In conclusion, neogambogic acid exerted anti-apoptotic, anti-fibrotic, and anti-inflammatory effects in septic mice through the inactivation of MAPK/NF-κB pathway.

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INTRODUCTION

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REFERENCES

키워드

Apoptosis Fibrosis Myocardial reperfusion Neo-gambogic acid p38 MAPK Sepsis