학술논문
The physiological and pharmacological roles of prostaglandins in hair growth
이용수 5
- 영문명
- The physiological and pharmacological roles of prostaglandins in hair growth
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Dong Wook Shin
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제26권 제6호, 405~413쪽, 전체 9쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2022.11.30
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국문 초록
영문 초록
Hair loss is a common status found among people of all ages. Since the role of hair is much more related to culture and individual identity, hair loss can have a great influence on well-being and quality of life. It is a disorder that is observed in only scalp patients with androgenetic alopecia (AGA) or alopecia areata caused by stress or immune response abnormalities. Food and Drug Administration (FDA)- approved therapeutic medicines such as finasteride, and minoxidil improve hair loss temporarily, but when they stop, they have a limitation in that hair loss occurs again. As an alternative strategy for improving hair growth, many studies reported that there is a relationship between the expression levels of prostaglandins (PGs) and hair growth. Four major PGs such as prostaglandin D2 (PGD2), prostaglandin I2 (PGI2), prostaglandin E2 (PGE2), and prostaglandin F2 alpha (PGF2α) are spatiotemporally expressed in hair follicles and are implicated in hair loss. This review investigated the physiological roles and pharmacological interventions of the PGs in the pathogenesis of hair loss and provided these novel insights for clinical therapeutics for patients suffering from alopecia.
목차
INTRODUCTION
HAIR FOLLICLE DEVELOPMENT AND HAIR CYCLE
THE IMPLICATION OF COX IN HAIR GROWTH
PROSTAGLANDINS AND PROSTAGLANDIN RECEPTORS IN HAIR GROWTH
THE INHIBITORY ROLES OF PROSTAGLANDIN (PGD2) IN HAIR GROWTH
THE STIMULATORY ROLES OF PROSTAGLANDINS (PGE2 AND PGF2Α) IN HAIR GROWTH
DISCUSSION
FUNDING
ACKNOWLEDGEMENTS
CONFLICTS OF INTEREST
REFERENCES
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