중추내로 투여한 5-HT1A 작동제에 의한 마취 가토에 있어서 신장기능의 변동

• 영문명: Renal Functional Responses to a Centrally-administered 5-HT_1A Agonist in the Anesthetized Rabbits
• 발행기관: 대한생리학회-대한약리학회
• 저자명: 임영채(Young Chai Lim) 김경심(Kyung Shim Kim) 국영종(Young Johng Kook) 고정태(Jeong Tae Koh)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제3호, 315~323쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

Central tryptaminergic system has been shown to play an important role in the regulation of renal function: 5-HT₁(5-hydroxytryptamine₁) receptors might seem to mediate the diuresis and natriuresis, whereas the 5-HT₂ and 5-HT₃ receptors mediate the antidiuretic and antinatriuretic effects. This study attempted to delineate the role of central 5-HT_1A subtype in the regulation of rabbit renal function by observing the renal effects of intracerebroventricularly(icv)-administered PAPP(p-aminophenylethyl-m-trifluoromethylphenyl piperazine, LY165163), a selective agonist of 5-HT_1A receptors. PAPP in doses ranging from 40 to 350 ㄍg/kg icv induced significantly diuresis, natriuresis, and kaliuresis, along with increased renal perfusion and glomerular filtration. Systemic blood pressure was also increased. Free water reabsorption(T^cH₂O), a measure of ADH(antidiuretic hormone) secretion, was increased also. Intravenous 350 ㄍg/kg of PAPP elicited antidiuresis and antinatriuresis together with decreased blood pressure, thus indicating that the effects of icv PAPP were brought about through the central mechanisms, not by direct peripheral effects of the drug on kidney. Ketanserin, a selective 5-HT₂ antagonist, 40 ㄍg/kg icv, did not affect the renal effects of the icv PAPP. Methysergide, a non-selective 5-HT₁ antagonist, also did not block the renal functional responses by the icv PAPP. NAN-190, a 5-HT_1A antagonist, also did not antagonized the renal action of the icv PAPP. However the increased free water reabsorption was abolished by both methysergide or ketanserin pretreatment. The increments of blood pressure by icv PAPP was blocked only by NAN-190 pretreatment. These observations suggest that the central 5-HT_1A receptor might be involved in the central regulation of rabbit renal function by exerting the diuretic and natriuretic influences.

키워드

Central tryptaminergic system Central 5-HT_1A receptor Renal function PAPP Diuresis Natriuresis