분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과

• 영문명: Inhibitory Effects of Reversible Proton Pump Inhibitors YH 1238 and YH1885 on Acid Secretion in Isolated Gastric Cells
• 발행기관: 대한생리학회-대한약리학회
• 저자명: 김혜영(Hye young Kim) 김동구(Dong Goo Kim) 이봉용(Bong Yong Lee) 이종욱(Jong Wook Lee)김경환(yung Hwan Kim)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제3호, 337~343쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of [¹⁴C]-aminopyrine and [¹⁴C]-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP(10^-3M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&F 96067. Dibutyryl cAMP stimulated the [¹⁴C]-aminopyrine accumulation and [¹⁴C]-glucose oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on [¹⁴C]-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of 10^-5M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.

키워드

Antiulcer YH1238 YH1885 Acid secretion Gastric cells