신경병증성 통증 모델 쥐에서 뇌간 핵의 전기자극이 후각세포의 기계자극에 대한 반응도에 미치는 영향

• 영문명: Effects of Electrical Stimulation of Brainstem Nuclei on Dorsal Horn Neuron Responses to Mechanical Stimuli in a Rat Model of Neuropathic Pain
• 발행기관: 대한생리학회-대한약리학회
• 저자명: 임중우(Joong Woo Leem) 최윤(Yoon Choi) 곽영섭(Young Seob Gwak) 남택상(Taik Sang Nam) 백광세(Kwang Se Paik)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제3호, 241~249쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

The aim of the present study is to examine the brainstem sites where the electrical stimulation produces a suppression of dorsal horn neuron responses of neuropathic rats. An experimental neuropathy was induced by a unilateral ligation of L5-L6 spinal nerves of rats. Ten to 15 days after surgery, the spinal cord was exposed and single-unit recording was made on wide dynamic range (WDR) neurons in the dorsal horn. Neuronal responses to mechanical stimuli applied to somatic receptive fields were examined to see if they were modulated by electrical stimulation of various brainstem sites. Electrical stimulation of periaqueductal gray (PAG), n. raphe magnus (RMg) or n. reticularis gigantocellularis (Gi) significantly suppressed responses of WDR neurons to both noxious and non-noxious stimuli. Electrical stimulation of other brainstem areas, such as locus coeruleus (LC) and n. reticularis paragigantocellularis lateralis (LPGi), produced little or no suppression. Microinjection of morphine into PAG, RMg, or Gi also produced a suppression as similar pattern to the case of electrical stimulation, whereas morphine injection into LC or LPGi exerted no effects. The results suggest that PAG, NRM and Gi are the principle brainstem nuclei involved in the descending inhibitory systems responsible for the control of neuropathic pain. These systems are likely activated by endogenous opioids and exert their inhibitory effect by acting on WDR neurons in the spinal cord.

키워드

Pain Neuropathy Brainstem nuclei Descending Spinal cord Wide dynamic range Dorsal horn neuron Morphine