학술논문
Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Evangelos Karanikas Evangelos Ntouros Dimitrios Oikonomou Georgios Floros Ioannis Griveas Georgios G
- 간행물 정보
- 『Psychiatry Investigation』제14권 제5호, 703~707쪽, 전체 5쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2017.09.30
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국문 초록
영문 초록
We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients. In contrast the UHR differed only from the CHRON group regarding the endocrine parameters. In conclusion, IL-4 appears to play a key role at prodrome.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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