학술논문
No Association between the Polymorphism rs6943555 in the AUTS2 Gene and Personality Traits in Japanese University Students
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Shin Narita Kazutaka Ikeda Daisuke Nishizawa Eiji Yoshihara Maki Numajiri Yuuya Onozawa Nobuyo Ohtan
- 간행물 정보
- 『Psychiatry Investigation』제14권 제5호, 681~686쪽, 전체 6쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2017.09.30
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국문 초록
영문 초록
Objective-The autism susceptibility candidate 2 (AUTS2) gene has been implicated in multiple neurological disorders. Several recent studies have revealed that the polymorphism rs6943555 in the AUTS2 gene is broadly associated with human mental function and behavior. Therefore, in the present study we investigated whether the polymorphism rs6943555 is associated with human personality traits in Japanese university students. In addition, our previous study reported that the AUTS2 rs6943555-rs9886351 haplotype is associated with alcohol dependence. As a preliminary analysis, we also examined whether the AUTS2 haplotypes are related to personality traits.
Methods-After written informed consent had been obtained from the participants, two AUTS2 polymorphisms were analyzed, and personality was assessed using the Temperament and Character Inventory (TCI) in 190 university students. In addition, in order to exclude the influence of the results for students with mental health problems, we gave the Patient Health Questionnaire-9 (PHQ-9) to all subjects.
Results-In all the subjects, there was a main effect of the polymorphism rs6943555 genotype on reward dependence (p=0.038) and cooperativeness (p=0.031), although the significance was lost on Bonferroni correction. Similarly, on analysis that excluded the subjects with PHQ-9 scores≥10, no significant association with any TCI dimension score among the rs6943555 genotypes was seen. There was no effect of the rs6943555-rs9886351 haplotypes on the TCI dimension scores.
Conclusion-This study suggests that the polymorphism AUTS2 rs6943555 is not associated with personality traits. Further large-scale studies with more subjects using other self-report questionnaires are needed.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
키워드
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