학술논문
Effects of Psychotropic Drugs on Seizure Threshold during Electroconvulsive Therapy
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- SuHyuk Chi HyunGhang Jeong Suji Lee SoYoung Oh SeungHyun Kim
- 간행물 정보
- 『Psychiatry Investigation』제14권 제5호, 647~655쪽, 전체 9쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2017.09.30
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국문 초록
영문 초록
Objectives-To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT.
MethodsWe examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast).
ResultsMultivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01).
Conclusion-Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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