흰쥐의 절망행동 모형에서 항우울제의 효과에 미치는 Triiodothyronine(T3) 의 영향

• 영문명: Triiodothyronine(T3) Effect on “Behavioral Despair” in Rats Following Various Antidepressants Administration
• 발행기관: 대한신경정신의학회
• 저자명: 김보연 채영래 백인호
• 간행물 정보: 『신경정신의학』제29권 제3호, 616~622쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.05.31

영문 초록

In an attempt to identify some of the biochemical processes underlying immobility in rats, the authors investigated the effects of a variety of pharmacological agents known to modify neurotransmission in central noradrenaline, dopamine and serotonin systems. The results suggest that immobility is sensitive to agents which modify the activity of central catecholamines but is insensitive to agents which act primarily on serotonin. And, several investigations have suggested a special relationship exists between thyroid function and affective disorders. Given the activity of T3 on psychopharmacological models of depression in rodents, we also investigated the effects of T3 on behavioral tests in rats. The present study shows that the reversal by amitriptyline of depressive-like behavior in rats was markedly potentiated to T3 administration. This supports notion of intricate thyroid and CNS interaction in the mechanism of action of antidepressant, especially by serotonergic system.

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