전기경련충격이 흰쥐 뇌의 Glutamine Synthetase의 활성도에 미치는 영향에 관한 연구

• 영문명: The Effect of Electroconvulsive Shock on Glutamine Synthetase of Rat Brain
• 발행기관: 대한신경정신의학회
• 저자명: 손진욱
• 간행물 정보: 『신경정신의학』제29권 제3호, 601~615쪽, 전체 15쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.05.31

영문 초록

In order to elucidate the mechanism of action of electroconvulsive shock (ECS) in psychiatric illness, the author investigated the effect of electroshock on glutamine synthetase (GS) in rat brain. GS activities in hippocampus, corpus striatum and cerebral cortex were measured after single, multiple and regressive electroshocks (subconvulsive and convulsive doses) to normal rats, and GS activities were also measured after ECS in methionine sulfoximine treated rats. Major findings were that ten daily ECS (multiple ECS) decreased GS activities in the hippocampus and four ECS in 30 min interval (regressive ECS) reinforced the GS inhibition of methionine sulfoximine. These findings suggest that GS may play a significant role in the mechanism of action of ECS and need further studies.

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