우울증시의 혈장 Serotonin과 Norepinephrine치

• 영문명: Plasma Serotonin and Norepinephrine Level in Depression
• 발행기관: 대한신경정신의학회
• 저자명: 김진규 정영조
• 간행물 정보: 『신경정신의학』제29권 제3호, 592~600쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.05.31

영문 초록

There are two original monoamine hypotheses in the biochemical pathogenesis related to the depressed patients. The one, catecholamine hypothesis, has focused on peripheral hyperadrenergic functioning; the other, indolamine hypothesis, have favored defective serotonergic functioning. For the evaluation of the correlations between these two neurotransmitters, the authors investigated the plasma 5-hydroxytrptamine and norepinephrine level with high performance liquid chromatography in the depression group and normal control group. The results are as follows; 1) The depression group shows significantly decreased level of 5-HT in plasma than the control group, but there is not significant increment of norepinephrine level. 2) 5-HT level and NE level in the depression group or normal control group do not show significant correlation. 3) The NE level is not affected significantly by the change of 5-HT level in depression group. 4) But somewhat meaningful correlation coefficients are gained by subgrouping the depression group. The subgroup with lower 5-HT level shows some positive correlation and the subgroup with higher 5-HT level shows considerable negative correlation. Thus the authors are reminded of the complex interaction of monoamine neurotransmitters including the dysregulation hypothesis and the permissive hypothesis, etc.

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