만성 정신분열병 및 지연성운동장애 환자에서 뇌 척수액 5-Hydroxyindoleacetic Acid 농도에 관한 연구

• 영문명: CSF 5-Hydroxyindoleacetic Acid Concentrations in Chronic Schizophrenia and Tardive Dyskinesia
• 발행기관: 대한신경정신의학회
• 저자명: 우종인 이도희 권준수
• 간행물 정보: 『신경정신의학』제29권 제6호, 1255~1261쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.11.30

영문 초록

The present study was undertaken to clarify the role of serotonin system in the pathophysiology of schizophrenia and tardive dyskinesia. 5-hydroxyindoleacetic acid (5-HIAA) concentrations in CSF were m easured in 30 schizophrenic patients with tardive dyskinesia, 13 schizophrenic patients without tardive dyskinesia and 26 neurologic patients without psychotic symptoms as control group. The rerults were as follows: 1) CSF 5-HIAA concentrations in schizophrenic patients without tardive dyskinesia were not significantly different from those in neurologic patients. 2) A significant reduction in CSF 5-HIAA levels was observed in dyskinetic schizophrenics compared with the neurologic patients or schizophrenic patients without tardive dyskinesia. 3) The severity of dyskinetic symptoms was not correlated with the level of CSF 5-HIAA. The result of this study might be suggested that serotonin system is involved in the pathophysiology of tardive dyskinesia in certain subtype

목차

서 론

연구대상 및 연구방법

결 과

고 찰

결 론

References