지연성 운동장애 환자에서 뇌 척수액 丫-Aminobutyric Acid 농도에 관한 연구

• 영문명: CSF GABA Concentrations in Tardive Dyskinesia
• 발행기관: 대한신경정신의학회
• 저자명: 권준수 김재진 우종인
• 간행물 정보: 『신경정신의학』제29권 제6호, 1245~1254쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.11.30

영문 초록

The present study was undertaken to clarify the role of 丫-aminobutyric acid(GABA) in the pathophysiology of tardive dyskinesia. GABA concentrations in CSF were m easured in 14 schizophrenic patients without tardive dyskinesia, 15 schizophrenic patients with tardive dyskinesia and 18 neurologic patients without psychotic symptoms. In addition, GABA concentrations in CSF and clinical improvement of tardive dyskinesia w ere checked for dyskinetic schizophrenics after 8 weeks of treatm ent with sodium valproate, the GABAergic drug. Results were as follows: 1 ) A significant reduction in CSF GABA levels was observed in dyskinetic schizophrenics compared with the neurologic patients. 2) CSF GABA levels in schizophrenic patients without tardive dyskinesia were not significantly differnet from those in neurologic patients, although the data suggested a decrease in CSF GABA levels in schizophrenic patients. 3) A significant decrease in dyskinetic symptoms occurred with the administration of sodium valproate, associated with increase in CSF levels of GABA. The results of this study can be taken as a strong suggestion that GABA system is involved in the pathophysiology of tardive dyskinesia.

목차

서 론

연구대상 및 방법

결 과

결 론

References