Haloperidol Decanoate의 임상효과 및 항정상태 약동학

• 영문명: Clinical Efficacy and Steady-State Pharmacokinetics of Haloperidol Decanoate
• 발행기관: 대한신경정신의학회
• 저자명: 김정익 김영훈 신상구
• 간행물 정보: 『신경정신의학』제29권 제6호, 1207~1221쪽, 전체 15쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.11.30

영문 초록

The 12 chronic schizophrenic patients, previously treated with several low-dose antipsychotics, received oral Haloperidol(lOmg once a day) for 4 weeks in the first phase and then given intram uscular Haloperidol decanoate(15 tim es the previous oral dose given every 4weeks interval) for a total of 12weeks in the second phase. 1. Clinical Efficacy. Using Brief Psychiatric Rating Scale, there were no significant differences in efficacy between oral Haloperidol in day 0 or day 28 and Haloperidol decanoate on day 28，indicating that these patients were stabilized. But there was a significant improvement in both overall Brief psychiatric Rating Scale Score(p〈0.05) and individual item scores such as tension(p〈0.05), depression(p<0.01), and anxiety and thought disorder from Eighth week of Haloperidol decanoate treatm ent compared with the final ratings on oral Haloperidol treatm ent on day 28. 2. Extrapyramidal Side-effect. In the phase of oral Haloperidol, they tended to have more extrapyramidal symptoms such as rigidity and acute dystonia. These adverse effects were significantly diminished from 8weeks’ Haloperidol decanoate(p

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