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Changes in metabolic syndrome and the risk of breast and endometrial cancer according to menopause in Korean women

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영문명
Changes in metabolic syndrome and the risk of breast and endometrial cancer according to menopause in Korean women
발행기관
한국역학회
저자명
Thi Xuan Mai Tran Soyeoun Kim Boyoung Park
간행물 정보
『Epidemiology and Health』45, 1~12쪽, 전체 12쪽
주제분류
의약학 > 면역학
파일형태
PDF
발행일자
2023.01.01
4,240

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국문 초록

영문 초록

OBJECTIVES: This study investigated how changes in metabolic syndrome (MetS) are associated with the subsequent risk of breast and endometrial cancer according to menopausal status. METHODS: This cohort study, using data from the National Health Insurance Service database, included women aged ≥40 years who underwent 2 biennial cancer screenings (2009-2010 and 2011-2012) and were followed up until 2020. Participants were grouped into MetS-free, MetS-recovery, MetS-development, and MetS-persistent groups. Menopausal status (premenopausal, perimenopausal, and postmenopausal) was assessed at 2 screenings. Cox proportional hazard regression was used to assess the association between MetS changes and cancer risk. RESULTS: In 3,031,980 women, breast and endometrial cancers were detected in 39,184 and 4,298, respectively. Compared with the MetS-free group, those who recovered, developed, or had persistent MetS showed an increased risk of breast cancer, with adjusted hazard ratios (aHRs) of 1.05, 1.05, and 1.11, respectively (p<0.005). MetS persistence was associated with an increased risk of breast cancer in postmenopausal women (aHR, 1.12, 95% confidence interval [CI], 1.08 to 1.16) but not in premenopausal or perimenopausal women. MetS persistence was associated with an increased risk of endometrial cancer in premenopausal, perimenopausal, and postmenopausal women, with aHRs of 1.41 (95% CI, 1.17 to 1.70), 1.59 (95% CI, 1.19 to 2.12), and 1.47 (95% CI, 1.32 to 1.63), respectively. CONCLUSIONS: Increased breast cancer risk was associated with recovered, developed, and persistent MetS in postmenopausal women. Meanwhile, increased endometrial cancer risk was found in obese women who recovered from MetS or persistently had MetS, regardless of menopausal status, when compared to MetS-free women.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
DATA AVAILABILITY
SUPPLEMENTARY MATERIALS
CONFLICT OF INTEREST
FUNDING
ACKNOWLEDGEMENTS
AUTHOR CONTRIBUTIONS
ORCID
REFERENCES

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APA

Thi Xuan Mai Tran,Soyeoun Kim,Boyoung Park. (2023).Changes in metabolic syndrome and the risk of breast and endometrial cancer according to menopause in Korean women. Epidemiology and Health, 45 (), 1-12

MLA

Thi Xuan Mai Tran,Soyeoun Kim,Boyoung Park. "Changes in metabolic syndrome and the risk of breast and endometrial cancer according to menopause in Korean women." Epidemiology and Health, (2023): 1-12

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