Diverse Roles of Prohibitin1 in Cancer Progression and Development

• 발행기관: 대한약학회
• 저자명: Ju-Young Kim Jin Won Yang
• 간행물 정보: 『약학회지』제63권 제6호(2019년), 319~327쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2019.12.30

영문 초록

Prohibitin 1 (PHB1) is a mitochondrial chaperone protein that is evolutionarily conserved and ubiquitously expressed, and functions in the regulation of cell proliferation, metabolism, and mitochondrial homoeostasis. Biological roles of PHB1 include involvement in multiple other pathways related to their subcellular localization, including mitochondria, plasma membrane, endoplasmic reticulum, and the nucleus. Alterations in PHB1 expression levels are associated with cancer, aging, neurodegeneration, and heart and kidney diseases. PHB1 has exhibited anti-proliferative activity in the liver and was considered a tumor suppressor in some cancers, including breast, gastric, and prostate cancer. However, PHB1 expression is often increased in many cancers and its role in oncogenesis is not clearly understood. Herein, we summarize the functional roles of PHB1 in cancer development and the therapeutic approaches for targeting PHB1.

목차

Introduction

Role of Prohibitin1 in Liver Cancer

Role of Prohibitin1 in Breast Cancer

Role of Prohibitin1 in Prostate Cancer

Role of Prohibitin1 in Lung Cancer

Conclusion

Acknowledgment

Conflict of Interest

References

키워드

Prohibitin1 subcellular localization tumor suppressor cancer oncogenesis