돼지에서 피하주사후 abamectin 의 약물동태학

• 영문명: Pharmacokinetics of abamectin after subcutaneous injection in pigs
• 발행기관: 한국예방수의학회
• 저자명: 최기섭(Ki Sub Choi) 윤효인(Hyo In Yun) 박승춘(Seung Chun Park) 조준형(Joon Hyoung Cho) 박종명(Jong Myeong Park)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.22, No.1, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 1998.03.30

영문 초록

Abamectin, a natural avermectin, is one of the most potent compounds currently available for the control of intestine and lung endoparasites, and some ectoparasites. Hence, the drug is expected to be widely used in the veterinary practice for the control of major parasites, especially in the field of swine practice at which parasites are responsible for the productivity loss. Pharmacokinetic profile for abamectin is not yet established, which leads to no set-up of optimal dosage and withdrawal time. Therefore, in the present study, we were carried out the pharmacokinetic study in pigs after subcutaneous injection with 0.3mg/kg of body weight. Recovery of abamectin in pig plasma after fluorescence derivatization was 83.95±1.66%. Detection reproduction in terms of coefficient variation was 3.01% and 2.14%(intra-day), and 3.65% and 5.59%(inter-day) for 0.1 and 10 ppm, respectively. Pharmacokinetic profiles of abamectin administered subcutaneously to five male pigs(17.4±1.56kg), were adequatedly described by the first-or-der absorption and first-order elimination with 1-compartment open model. AUC was 244.81±82.41ng day/ml and the biological elimination half-life(t1/2.Kel was 4.28±1.17 days, suggesting the long half-life. Absorption half-life((t1/2.Kab was 0.87±1.18 days, showing rather slow absorption. Time to peak plasma concentration(tmax) was 1.79±1.51 days and peak plasma concentration (Cmax) was 30.17±12.95ng/ml.

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키워드

Pharmacokinetics Pig Abamectin Fluorescence derivatization